New bioactive peptides from the venom gland of a social hornet Vespa velutina
نویسندگان
چکیده
Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for design novel antibiotics combat microbial resistance. In this research, we identified four (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and U-VVTX-Vp2b, respectively) from venom Vespa velutina, tested their antimicrobial, antioxidant, hemolytic effects. All showed scavenging ability against DPPH, ABTS+, •OH free radicals. Of note, Vp1b strongly inhibited growth Staphylococcus aureus Escherichia coli bacteria at concentrations 60 120 μM. Due low activity, all could be utilized in antioxidants as antimicrobial agents.
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ژورنال
عنوان ژورنال: Toxicon
سال: 2021
ISSN: ['0041-0101', '1879-3150']
DOI: https://doi.org/10.1016/j.toxicon.2021.06.002